BIOMEDICINE: Resisting Arrest

Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas.

The cellular and molecular events that initiate and promote malignant glioma development are not completely understood. The treatment modalities designed to promote its demise are all ultimately ineffective, leading to disease progression. In this issue of the JCI, Kioi et al. demonstrate that vasculogenesis and angiogenesis potentially play distinct roles in the etiology of primary and recurre...

: Resisting History

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Resisting Explanation

Although explanation is widely regarded as an important concept in the study of rational inquiry, it remains largely unexplored outside the philosophy of science. This, I believe, is not due to oversight as much as to institutional resistance. In analytic philosophy it is basic that epistemic rationality is a function of justification and that justification is a function of argument. Explanatio...

Tropical Biomedicine

Biomedicine Select

Autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, are complex disorders characterized by an inflammatory response against the body's own tissues. Recent findings reveal new insights into how these diseases are initiated and progress and the factors that contribute to their clinical symptoms. Such work also pinpoints potential new therapeutic targets including the integra...